Symptoms
Under certain circumstances a Windows Server 2008 R2 based server running XenApp 6 becomes unresponsive after some time.
After users disconnect or end their session, all current user sessions stop responding and no new RDP or ICA Sessions can be started to the server. If the server is rebooted, this behaviour is resolved for an unspecified time, the issue might reoccur.
Cause
Based on the investigation performed by Citrix and Microsoft Technical Support, under certain circumstances a race condition occurs between simultaneous TCP session connects and disconnects.
Resolution
Microsoft Support has identified this issue and has released a hotfix for this issue: http://support.microsoft.com/kb/2465772
This issue is for Windows Server 2008 R2 only; it does not affect earlier platforms.