Sikuli jython: Automate anything you see

Sikuli is a visual technology to automate and test graphical user interfaces  (GUI) using images (screenshots). Sikuli includes Sikuli Script, a visual  scripting API for Jython, and Sikuli IDE, an integrated development environment  for writing visual scripts with screenshots easily. Sikuli Script automates  anything you see on the screen without internal API's support. You can  programmatically control a web page, a Windows/Linux/Mac OS X desktop  application, or even an iphone or android application running in a simulator or  via VNC.
Reference: http://sikuli.org/